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Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
During chemotaxis, receptors and heterotrimeric G-protein subunits are distributed and activated almost uniformly along the cell membrane, whereas PI(3,4,5)P(3), the product of phosphatidylinositol 3-kinase (PI3K), accumulates locally at the leading edge. The key intermediate event that creates this...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172490/ https://ncbi.nlm.nih.gov/pubmed/15534002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406177 |
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