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Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

During chemotaxis, receptors and heterotrimeric G-protein subunits are distributed and activated almost uniformly along the cell membrane, whereas PI(3,4,5)P(3), the product of phosphatidylinositol 3-kinase (PI3K), accumulates locally at the leading edge. The key intermediate event that creates this...

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Библиографические подробности
Главные авторы: Sasaki, Atsuo T., Chun, Cheryl, Takeda, Kosuke, Firtel, Richard A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2004
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172490/
https://ncbi.nlm.nih.gov/pubmed/15534002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200406177
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