Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

We identified the UBE2L6 gene, encoding the ISG15-conjugating enzyme UbcH8, as one gene significantly downregulated by promoter hypermethylation in nasopharyngeal carcinoma (NPC). Reduced expression of the UbcH8 protein correlated with poor outcome in NPC patients. Restored expression of UBE2L6 supp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhou, Xiaoying, Wei, Jiazhang, Chen, Fu, Xiao, Xue, Huang, Tingting, He, Qian, Wang, Shumin, Du, Chunping, Mo, Yingxi, Lin, Longde, Xie, Ying, Wei, Lili, Lan, Ying, Murata, Mairiko, Huang, Guangwu, Ernberg, Ingemar, Matskova, Liudmila, Zhang, Zhe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747391/
https://ncbi.nlm.nih.gov/pubmed/26506425
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