Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

We identified the UBE2L6 gene, encoding the ISG15-conjugating enzyme UbcH8, as one gene significantly downregulated by promoter hypermethylation in nasopharyngeal carcinoma (NPC). Reduced expression of the UbcH8 protein correlated with poor outcome in NPC patients. Restored expression of UBE2L6 supp...

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Udgivet i:Oncotarget
Main Authors: Zhou, Xiaoying, Wei, Jiazhang, Chen, Fu, Xiao, Xue, Huang, Tingting, He, Qian, Wang, Shumin, Du, Chunping, Mo, Yingxi, Lin, Longde, Xie, Ying, Wei, Lili, Lan, Ying, Murata, Mairiko, Huang, Guangwu, Ernberg, Ingemar, Matskova, Liudmila, Zhang, Zhe
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747391/
https://ncbi.nlm.nih.gov/pubmed/26506425
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