Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells

According to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) contributes to the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Monoamine oxidase-A (MAO-A) catalyzes the conversion of intraneuronal dopamine to DOPAL and may se...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Pharmacol Exp Ther
Auteurs principaux: Goldstein, David S., Jinsmaa, Yunden, Sullivan, Patti, Holmes, Courtney, Kopin, Irwin J., Sharabi, Yehonatan
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2016
Sujets:
Neuropharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746494/
https://ncbi.nlm.nih.gov/pubmed/26574516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.230201
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