Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Elucidating the targets and mechanism of action of natural products is strategically important prior to drug development and assessment of potential clinical applications. In this report, we elucidated the main targets and mechanism of action of the natural product tonantzitlolone (TZL) in clear cel...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Sourbier, Carole, Scroggins, Bradley T., Mannes, Philip Z., Liao, Pei-Jyun, Siems, Karsten, Wolf, Dietmar, Beutler, John A., Linehan, W. Marston, Neckers, Leonard
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745775/
https://ncbi.nlm.nih.gov/pubmed/26298773
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