Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels

BACKGROUND AND PURPOSE: The diterpene ester tonantzitlolone (TZL) is a natural product, which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells. The effect is similar to that of (‐)‐englerin A, and so, although it is chemically distinct, we investigated wh...

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Pubblicato in:Br J Pharmacol
Autori principali: Rubaiy, Hussein N, Ludlow, Melanie J, Siems, Karsten, Norman, Katherine, Foster, Richard, Wolf, Dietmar, Beutler, John A, Beech, David J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057908/
https://ncbi.nlm.nih.gov/pubmed/29859013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14379
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