Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels

BACKGROUND AND PURPOSE: The diterpene ester tonantzitlolone (TZL) is a natural product, which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells. The effect is similar to that of (‐)‐englerin A, and so, although it is chemically distinct, we investigated wh...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Rubaiy, Hussein N, Ludlow, Melanie J, Siems, Karsten, Norman, Katherine, Foster, Richard, Wolf, Dietmar, Beutler, John A, Beech, David J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057908/
https://ncbi.nlm.nih.gov/pubmed/29859013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14379
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