Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

Pemetrexed, a multitarget antifolate used to treat malignant mesothelioma and non-small cell lung cancer (NSCLC), has been shown to stimulate autophagy. In this study, we determined whether autophagy could be induced by pemetrexed and simvastatin cotreatment in malignant mesothelioma and NSCLC cells...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hwang, Ki-Eun, Kim, Young-Suk, Jung, Jae-Wan, Kwon, Su-Jin, Park, Do-Sim, Cha, Byong-Ki, Oh, Seon-Hee, Yoon, Kwon-Ha, Jeong, Eun-Taik, Kim, Hak-Ryul
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745741/
https://ncbi.nlm.nih.gov/pubmed/26334320
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