Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

Pemetrexed, a multitarget antifolate used to treat malignant mesothelioma and non-small cell lung cancer (NSCLC), has been shown to stimulate autophagy. In this study, we determined whether autophagy could be induced by pemetrexed and simvastatin cotreatment in malignant mesothelioma and NSCLC cells...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Hwang, Ki-Eun, Kim, Young-Suk, Jung, Jae-Wan, Kwon, Su-Jin, Park, Do-Sim, Cha, Byong-Ki, Oh, Seon-Hee, Yoon, Kwon-Ha, Jeong, Eun-Taik, Kim, Hak-Ryul
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745741/
https://ncbi.nlm.nih.gov/pubmed/26334320
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