Loading...

Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

Pemetrexed, a multitarget antifolate used to treat malignant mesothelioma and non-small cell lung cancer (NSCLC), has been shown to stimulate autophagy. In this study, we determined whether autophagy could be induced by pemetrexed and simvastatin cotreatment in malignant mesothelioma and NSCLC cells...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Hwang, Ki-Eun, Kim, Young-Suk, Jung, Jae-Wan, Kwon, Su-Jin, Park, Do-Sim, Cha, Byong-Ki, Oh, Seon-Hee, Yoon, Kwon-Ha, Jeong, Eun-Taik, Kim, Hak-Ryul
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745741/
https://ncbi.nlm.nih.gov/pubmed/26334320
Tags: Add Tag
No Tags, Be the first to tag this record!