MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

Sorafenib resistance remains a major obstacle for the effective treatments of hepatocellular carcinoma (HCC). Recent studies indicate that activated Akt contributes to the acquired resistance to sorafenib, and miR-21 dysregulates phosphatase and tensin homolog (PTEN), which inhibits Akt activation....

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: He, Changjun, Dong, Xuesong, Zhai, Bo, Jiang, Xian, Dong, Deli, Li, Baoxin, Jiang, Hongchi, Xu, Shidong, Sun, Xueying
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745697/
https://ncbi.nlm.nih.gov/pubmed/26311740
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker