MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

Sorafenib resistance remains a major obstacle for the effective treatments of hepatocellular carcinoma (HCC). Recent studies indicate that activated Akt contributes to the acquired resistance to sorafenib, and miR-21 dysregulates phosphatase and tensin homolog (PTEN), which inhibits Akt activation....

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: He, Changjun, Dong, Xuesong, Zhai, Bo, Jiang, Xian, Dong, Deli, Li, Baoxin, Jiang, Hongchi, Xu, Shidong, Sun, Xueying
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745697/
https://ncbi.nlm.nih.gov/pubmed/26311740
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