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C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

OBJECTIVE: How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐ and loss‐of‐function mechanisms have been proposed. Evidence supporting these mechanisms in vivo is, however, incomplete. Here we determined the effect...

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Detaylı Bibliyografya
Yayımlandı:Ann Neurol
Asıl Yazarlar: Koppers, Max, Blokhuis, Anna M., Westeneng, Henk‐Jan, Terpstra, Margo L., Zundel, Caroline A. C., Vieira de Sá, Renata, Schellevis, Raymond D., Waite, Adrian J., Blake, Derek J., Veldink, Jan H., van den Berg, Leonard H., Pasterkamp, R. Jeroen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744979/
https://ncbi.nlm.nih.gov/pubmed/26044557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24453
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