C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

OBJECTIVE: How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐ and loss‐of‐function mechanisms have been proposed. Evidence supporting these mechanisms in vivo is, however, incomplete. Here we determined the effect...

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Vydáno v:Ann Neurol
Hlavní autoři: Koppers, Max, Blokhuis, Anna M., Westeneng, Henk‐Jan, Terpstra, Margo L., Zundel, Caroline A. C., Vieira de Sá, Renata, Schellevis, Raymond D., Waite, Adrian J., Blake, Derek J., Veldink, Jan H., van den Berg, Leonard H., Pasterkamp, R. Jeroen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744979/
https://ncbi.nlm.nih.gov/pubmed/26044557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24453
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