Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion()

An intronic G(4)C(2) hexanucleotide repeat expansion in C9ORF72 is a major cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Several mechanisms including RNA toxicity, repeat-associated non-AUG translation mediated dipeptide protein aggregates, and haploinsufficiency of C...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Waite, Adrian J., Bäumer, Dirk, East, Simon, Neal, James, Morris, Huw R., Ansorge, Olaf, Blake, Derek J.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
Teme:
Genetic Report Abstract
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988882/
https://ncbi.nlm.nih.gov/pubmed/24559645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.01.016
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items