Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion

BACKGROUND: In patients with a C9orf72 repeat expansion (C9+), a neuroimaging phenotype with widespread structural cerebral changes has been found. We aimed to investigate the specificity of this neuroimaging phenotype in patients with amyotrophic lateral sclerosis (ALS). METHODS: 156 C9− and 14 C9+...

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Detalhes bibliográficos
Publicado no:J Neurol Neurosurg Psychiatry
Principais autores: Westeneng, Henk-Jan, Walhout, Renée, Straathof, Milou, Schmidt, Ruben, Hendrikse, Jeroen, Veldink, Jan H, van den Heuvel, Martijn P, van den Berg, Leonard H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Neurodegeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136726/
https://ncbi.nlm.nih.gov/pubmed/27756805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2016-313959
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