C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

OBJECTIVE: How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐ and loss‐of‐function mechanisms have been proposed. Evidence supporting these mechanisms in vivo is, however, incomplete. Here we determined the effect...

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Bibliographic Details
Published in:Ann Neurol
Main Authors: Koppers, Max, Blokhuis, Anna M., Westeneng, Henk‐Jan, Terpstra, Margo L., Zundel, Caroline A. C., Vieira de Sá, Renata, Schellevis, Raymond D., Waite, Adrian J., Blake, Derek J., Veldink, Jan H., van den Berg, Leonard H., Pasterkamp, R. Jeroen
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744979/
https://ncbi.nlm.nih.gov/pubmed/26044557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24453
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