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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can sl...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4743827/ https://ncbi.nlm.nih.gov/pubmed/26755598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514511113 |
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