Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Starvation blocks the actions of growth hormone (GH) and inhibits growth through mechanisms that are not well understood. In this report, we demonstrate that fibroblast growth factor 21 (FGF21), a hormone induced by fasting, causes GH resistance. In liver, FGF21 reduces concentrations of the active...

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Autori principali: Inagaki, Takeshi, Lin, Vicky Y., Goetz, Regina, Mohammadi, Moosa, Mangelsdorf, David J., Kliewer, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575072/
https://ncbi.nlm.nih.gov/pubmed/18585098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.05.006
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