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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can sl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Youm, Yun-Hee, Horvath, Tamas L., Mangelsdorf, David J., Kliewer, Steven A., Dixit, Vishwa Deep
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743827/
https://ncbi.nlm.nih.gov/pubmed/26755598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514511113
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