Versatile strategy for controlling the specificity and activity of engineered T cells

The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical efficacy, the general application of current CAR–T-cell therapy is limited by serious treatment-related toxicities. One approach...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ma, Jennifer S. Y., Kim, Ji Young, Kazane, Stephanie A., Choi, Sei-hyun, Yun, Hwa Young, Kim, Min Soo, Rodgers, David T., Pugh, Holly M., Singer, Oded, Sun, Sophie B., Fonslow, Bryan R., Kochenderfer, James N., Wright, Timothy M., Schultz, Peter G., Young, Travis S., Kim, Chan Hyuk, Cao, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743826/
https://ncbi.nlm.nih.gov/pubmed/26759368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524193113
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