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Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood–brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-prot...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lou, Nanhong, Takano, Takahiro, Pei, Yong, Xavier, Anna L., Goldman, Steven A., Nedergaard, Maiken
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743790/
https://ncbi.nlm.nih.gov/pubmed/26755608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520398113
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