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Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

Microglia are integral functional elements of the central nervous system, but the contribution of these cells to the structural integrity of the neurovascular unit has not hitherto been assessed. We show here that following blood–brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-prot...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lou, Nanhong, Takano, Takahiro, Pei, Yong, Xavier, Anna L., Goldman, Steven A., Nedergaard, Maiken
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743790/
https://ncbi.nlm.nih.gov/pubmed/26755608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520398113
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