Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

Chronic nicotine exposure (CNE) alters synaptic transmission in the ventral tegmental area (VTA) in a manner that enhances dopaminergic signaling and promotes nicotine use. The present experiments identify a correlation between enhanced production of the endogenous cannabinoid 2-arachidonoylglycerol...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Buczynski, Matthew W., Herman, Melissa A., Hsu, Ku-Lung, Natividad, Luis A., Irimia, Cristina, Polis, Ilham Y., Pugh, Holly, Chang, Jae Won, Niphakis, Micah J., Cravatt, Benjamin F., Roberto, Marisa, Parsons, Loren H.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743781/
https://ncbi.nlm.nih.gov/pubmed/26755579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522672113
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