Constitutive increases in corticotropin releasing factor and fatty acid amide hydrolase drive an anxious phenotype

BACKGROUND: Corticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF(1) receptors in limbic brain regions. Anxiety is further modulated by the endogenous cannabinoid (eCB) system that attenuates the synaptic effects of stress. In the amygdala, acute stress activates the e...

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Publicado no:Biol Psychiatry
Main Authors: Natividad, Luis A., Buczynski, Matthew W., Herman, Melissa A., Kirson, Dean, Oleata, Christopher S., Irimia, Cristina, Polis, Ilham, Ciccocioppo, Roberto, Roberto, Marisa, Parsons, Loren H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509512/
https://ncbi.nlm.nih.gov/pubmed/28209423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.01.005
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