Constitutive increases in corticotropin releasing factor and fatty acid amide hydrolase drive an anxious phenotype

BACKGROUND: Corticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF(1) receptors in limbic brain regions. Anxiety is further modulated by the endogenous cannabinoid (eCB) system that attenuates the synaptic effects of stress. In the amygdala, acute stress activates the e...

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Dettagli Bibliografici
Pubblicato in:Biol Psychiatry
Autori principali: Natividad, Luis A., Buczynski, Matthew W., Herman, Melissa A., Kirson, Dean, Oleata, Christopher S., Irimia, Cristina, Polis, Ilham, Ciccocioppo, Roberto, Roberto, Marisa, Parsons, Loren H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509512/
https://ncbi.nlm.nih.gov/pubmed/28209423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.01.005
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