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Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

BACKGROUND: Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division. These proteins function to block the anaphase entry until all condensed chromosomes have been attached by the microtubules emanating from both spindle...

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Bibliografski detalji
Izdano u:J Hematol Oncol
Glavni autori: Park, Sung-Hyun, Xie, Steve, Rao, Chinthalapally V., Dai, Wei
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743409/
https://ncbi.nlm.nih.gov/pubmed/26847209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0238-5
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