Opposing roles for p16(Ink4a) and p19(Arf) in senescence and ageing caused by BubR1 insufficiency

Expression of p16(Ink4a) and p19(Arf) increases with age in both rodent and human tissues. However, whether these tumour suppressors are effectors of ageing remains unclear, mainly because knockout mice lacking p16(Ink4a) or p19(Arf) die early of tumours. Here, we show that skeletal muscle and fat,...

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Detalhes bibliográficos
Main Authors: Baker, Darren J., Perez-Terzic, Carmen, Jin, Fang, Pitel, Kevin, Niederländer, Nicolas J., Jeganathan, Karthik, Yamada, Satsuki, Reyes, Santiago, Rowe, Lois, Hiddinga, H. Jay, Eberhardt, Norman L., Terzic, Andre, van Deursen, Jan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2594014/
https://ncbi.nlm.nih.gov/pubmed/18516091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1744
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