Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agon...

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Bibliografske podrobnosti
izdano v:Am J Respir Cell Mol Biol
Main Authors: Deering-Rice, Cassandra E., Shapiro, Darien, Romero, Erin G., Stockmann, Chris, Bevans, Tatjana S., Phan, Quang M., Stone, Bryan L., Fassl, Bernhard, Nkoy, Flory, Uchida, Derek A., Ward, Robert M., Veranth, John M., Reilly, Christopher A.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742944/
https://ncbi.nlm.nih.gov/pubmed/26039217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0086OC
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