Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agon...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Deering-Rice, Cassandra E., Shapiro, Darien, Romero, Erin G., Stockmann, Chris, Bevans, Tatjana S., Phan, Quang M., Stone, Bryan L., Fassl, Bernhard, Nkoy, Flory, Uchida, Derek A., Ward, Robert M., Veranth, John M., Reilly, Christopher A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742944/
https://ncbi.nlm.nih.gov/pubmed/26039217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0086OC
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