Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agon...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Deering-Rice, Cassandra E., Shapiro, Darien, Romero, Erin G., Stockmann, Chris, Bevans, Tatjana S., Phan, Quang M., Stone, Bryan L., Fassl, Bernhard, Nkoy, Flory, Uchida, Derek A., Ward, Robert M., Veranth, John M., Reilly, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742944/
https://ncbi.nlm.nih.gov/pubmed/26039217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0086OC
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