Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma

Inhaled irritants activate transient receptor potential ankyrin-1 (TRPA1), resulting in cough, bronchoconstriction, and inflammation/edema. TRPA1 is also implicated in the pathogenesis of asthma. Our hypothesis was that particulate materials activate TRPA1 via a mechanism distinct from chemical agon...

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Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Deering-Rice, Cassandra E., Shapiro, Darien, Romero, Erin G., Stockmann, Chris, Bevans, Tatjana S., Phan, Quang M., Stone, Bryan L., Fassl, Bernhard, Nkoy, Flory, Uchida, Derek A., Ward, Robert M., Veranth, John M., Reilly, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742944/
https://ncbi.nlm.nih.gov/pubmed/26039217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0086OC
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