Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1

To improve the pharmacokinetics and to study the anti-cervical cancer and anti-stem cells (CSCs) mechanism of Quinacrine (QC), a spherical nano particle of QC (i.e. NQC) was prepared and characterized. QC and NQC showed higher cytotoxicity in multiple cancer cells than the normal epithelial cells. N...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nayak, Anmada, Satapathy, Shakti Ranjan, Das, Dipon, Siddharth, Sumit, Tripathi, Neha, Bharatam, Prasad V., Kundu, ChanakyaNath
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742869/
https://ncbi.nlm.nih.gov/pubmed/26846872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20600
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