Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function

The irreversible Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has shown efficacy against B-cell tumors such as chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma. Fcγ receptors (FcγR) on immune cells such as macrophages play an important role in tumor-specific antibody-mediated...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Ren, Li, Campbell, Amanda, Fang, Huiqing, Gautam, Shalini, Elavazhagan, Saranya, Fatehchand, Kavin, Mehta, Payal, Stiff, Andrew, Reader, Brenda F., Mo, Xiaokui, Byrd, John C., Carson, William E., Butchar, Jonathan P., Tridandapani, Susheela
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742765/
https://ncbi.nlm.nih.gov/pubmed/26627823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687251
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