Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse large B-cell lymphoma (DLBCL). However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized. Herein, we demonstrate that IKKβ phosphorylates GLI1 in DLBCL. IKKβ activation increas...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Agarwal, Nitin K., Kim, Chae H., Kunkalla, Kranthi, Konno, Hiroyasu, Tjendra, Youley, Kwon, Deukwoo, Blonska, Marzenna, Kozloski, Goldi A., Moy, Vincent T., Verdun, Ramiro E., Barber, Glen N., Lossos, Izidore S., Vega, Francisco
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2016
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742548/
https://ncbi.nlm.nih.gov/pubmed/26603838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-658781
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