Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse large B-cell lymphoma (DLBCL). However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized. Herein, we demonstrate that IKKβ phosphorylates GLI1 in DLBCL. IKKβ activation increas...

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Сохранить в:
Библиографические подробности
Опубликовано в: :Blood
Главные авторы: Agarwal, Nitin K., Kim, Chae H., Kunkalla, Kranthi, Konno, Hiroyasu, Tjendra, Youley, Kwon, Deukwoo, Blonska, Marzenna, Kozloski, Goldi A., Moy, Vincent T., Verdun, Ramiro E., Barber, Glen N., Lossos, Izidore S., Vega, Francisco
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2016
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742548/
https://ncbi.nlm.nih.gov/pubmed/26603838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-658781
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