Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse large B-cell lymphoma (DLBCL). However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized. Herein, we demonstrate that IKKβ phosphorylates GLI1 in DLBCL. IKKβ activation increas...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Agarwal, Nitin K., Kim, Chae H., Kunkalla, Kranthi, Konno, Hiroyasu, Tjendra, Youley, Kwon, Deukwoo, Blonska, Marzenna, Kozloski, Goldi A., Moy, Vincent T., Verdun, Ramiro E., Barber, Glen N., Lossos, Izidore S., Vega, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742548/
https://ncbi.nlm.nih.gov/pubmed/26603838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-658781
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