Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse large B-cell lymphoma (DLBCL). However, mechanisms underlying GLI1-increased activity in DLBCL are poorly characterized. Herein, we demonstrate that IKKβ phosphorylates GLI1 in DLBCL. IKKβ activation increas...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Agarwal, Nitin K., Kim, Chae H., Kunkalla, Kranthi, Konno, Hiroyasu, Tjendra, Youley, Kwon, Deukwoo, Blonska, Marzenna, Kozloski, Goldi A., Moy, Vincent T., Verdun, Ramiro E., Barber, Glen N., Lossos, Izidore S., Vega, Francisco
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2016
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742548/
https://ncbi.nlm.nih.gov/pubmed/26603838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-658781
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