Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

Mutations or inactivation of parkin, an E3 ubiquitin ligase, are associated with familial form or sporadic Parkinson’s disease (PD), respectively, which manifested with the selective vulnerability of neuronal cells in substantia nigra (SN) and striatum (STR) regions. However, the underlying molecula...

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Publicat a:Protein Cell
Autors principals: Song, Pingping, Li, Shanshan, Wu, Hao, Gao, Ruize, Rao, Guanhua, Wang, Dongmei, Chen, Ziheng, Ma, Biao, Wang, Hongxia, Sui, Nan, Deng, Haiteng, Zhang, Zhuohua, Tang, Tieshan, Tan, Zheng, Han, Zehan, Lu, Tieyuan, Zhu, Yushan, Chen, Quan
Format: Artigo
Idioma:Inglês
Publicat: Higher Education Press 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742389/
https://ncbi.nlm.nih.gov/pubmed/26746706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-015-0230-9
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