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Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin–proteasome system (UPS) for widespread degr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3071670/ https://ncbi.nlm.nih.gov/pubmed/21296869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr048 |
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