Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin–proteasome system (UPS) for widespread degr...

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Main Authors: Chan, Nickie C., Salazar, Anna M., Pham, Anh H., Sweredoski, Michael J., Kolawa, Natalie J., Graham, Robert L.J., Hess, Sonja, Chan, David C.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071670/
https://ncbi.nlm.nih.gov/pubmed/21296869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr048
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