PRIMA-1(met) (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms

PRIMA-1(met) (APR-246) is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis). PRIMA-1(met) has been reported to restore both the wild type (wt) structure and function of mutant p53. Here, we show that PRIMA-1(met) is highly effective at li...

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Publicat a:Oncotarget
Autors principals: Li, Xiao-Lan, Zhou, Jianbiao, Chan, Zit-Liang, Chooi, Jing-Yuan, Chen, Zhi-Rong, Chng, Wee-Joo
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742204/
https://ncbi.nlm.nih.gov/pubmed/26452133
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