Synergistic effects of PRIMA-1(Met) (APR-246) and 5-azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia

Myelodysplastic syndromes and acute myeloid leukemia with TP53 mutations are characterized by frequent relapses, poor or short responses, and poor survival with the currently available therapies including chemotherapy and 5-azacitidine (AZA). PRIMA-1(Met)(APR-246,APR) is a methylated derivative of P...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Haematologica
Prif Awduron: Maslah, Nabih, Salomao, Norman, Drevon, Louis, Verger, Emmanuelle, Partouche, Nicolas, Ly, Pierre, Aubin, Philippe, Naoui, Nadia, Schlageter, Marie-Helene, Bally, Cecile, Miekoutima, Elsa, Rahmé, Ramy, Lehmann-Che, Jacqueline, Ades, Lionel, Fenaux, Pierre, Cassinat, Bruno, Giraudier, Stephane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ferrata Storti Foundation 2020
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271596/
https://ncbi.nlm.nih.gov/pubmed/31488557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.218453
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