Synergistic effects of PRIMA-1(Met) (APR-246) and 5-azacitidine in TP53-mutated myelodysplastic syndromes and acute myeloid leukemia

Myelodysplastic syndromes and acute myeloid leukemia with TP53 mutations are characterized by frequent relapses, poor or short responses, and poor survival with the currently available therapies including chemotherapy and 5-azacitidine (AZA). PRIMA-1(Met)(APR-246,APR) is a methylated derivative of P...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Maslah, Nabih, Salomao, Norman, Drevon, Louis, Verger, Emmanuelle, Partouche, Nicolas, Ly, Pierre, Aubin, Philippe, Naoui, Nadia, Schlageter, Marie-Helene, Bally, Cecile, Miekoutima, Elsa, Rahmé, Ramy, Lehmann-Che, Jacqueline, Ades, Lionel, Fenaux, Pierre, Cassinat, Bruno, Giraudier, Stephane
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2020
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271596/
https://ncbi.nlm.nih.gov/pubmed/31488557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.218453
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