The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally, BBC cell lines and tumor models have been shown t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Oncotarget
Κύριοι συγγραφείς: Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Lipsky, Michael, Charpentier, Monica S., Boggs, Amanda E., Chakrabarti, Kristi R., Bhandary, Lekhana, Hessler, Lindsay K., Martin, Stuart S., Vitolo, Michele I.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Impact Journals LLC 2015
Θέματα:
Priority Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742101/
https://ncbi.nlm.nih.gov/pubmed/26497685
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