The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally, BBC cell lines and tumor models have been shown t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Lipsky, Michael, Charpentier, Monica S., Boggs, Amanda E., Chakrabarti, Kristi R., Bhandary, Lekhana, Hessler, Lindsay K., Martin, Stuart S., Vitolo, Michele I.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742101/
https://ncbi.nlm.nih.gov/pubmed/26497685
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