Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3′-shore

Recent evidence has shown that the level of 5-hydroxymethylcytosine (5hmC) in chromosomal DNA is aberrantly decreased in a variety of cancers, but whether this decrease is a cause or a consequence of tumorigenesis is unclear. Here we show that, in gastric cancers, the 5hmC decrease correlates with a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Park, Jong-Lyul, Kim, Hee-Jin, Seo, Eun-Hye, Kwon, Oh-Hyung, Lim, Byungho, Kim, Mirang, Kim, Seon-Young, Song, Kyu-Sang, Kang, Gyeong Hoon, Kim, Hyun Ja, Choi, Bo Youl, Kim, Yong Sung
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741955/
https://ncbi.nlm.nih.gov/pubmed/26462176
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