Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance. Cancer cells have metabolic flexibility in choosing either oxidative phosphorylation (OXPHOS) or glycolysis for ATP generation depending upon the...

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Publicado en:Oncotarget
Autores principales: Chaube, Balkrishna, Malvi, Parmanand, Singh, Shivendra Vikram, Mohammad, Naoshad, Meena, Avtar Singh, Bhat, Manoj Kumar
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741930/
https://ncbi.nlm.nih.gov/pubmed/26484566
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