Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance. Cancer cells have metabolic flexibility in choosing either oxidative phosphorylation (OXPHOS) or glycolysis for ATP generation depending upon the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chaube, Balkrishna, Malvi, Parmanand, Singh, Shivendra Vikram, Mohammad, Naoshad, Meena, Avtar Singh, Bhat, Manoj Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741930/
https://ncbi.nlm.nih.gov/pubmed/26484566
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