Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

Autophagy is an evolutionarily conserved survival pathway in eukaryote and is frequently upregulated in cancer cells after chemotherapy or targeted therapy. Thus induction of autophagy has emerged as a drug resistance mechanism. In this study, we found that crizotinib induced a high level of autopha...

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Veröffentlicht in:Oncotarget
Hauptverfasser: You, Liangkun, Shou, Jiawei, Deng, Danchen, Jiang, Liming, Jing, Zhao, Yao, Junlin, Li, Hongsen, Xie, Jiansheng, Wang, Zhanggui, Pan, Qin, Pan, Hongming, Huang, Wendong, Han, Weidong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741894/
https://ncbi.nlm.nih.gov/pubmed/26384345
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