Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

Autophagy is an evolutionarily conserved survival pathway in eukaryote and is frequently upregulated in cancer cells after chemotherapy or targeted therapy. Thus induction of autophagy has emerged as a drug resistance mechanism. In this study, we found that crizotinib induced a high level of autopha...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: You, Liangkun, Shou, Jiawei, Deng, Danchen, Jiang, Liming, Jing, Zhao, Yao, Junlin, Li, Hongsen, Xie, Jiansheng, Wang, Zhanggui, Pan, Qin, Pan, Hongming, Huang, Wendong, Han, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741894/
https://ncbi.nlm.nih.gov/pubmed/26384345
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