The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

Classical myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders that exhibit excess mature myeloid cells, bone marrow fibrosis, and risk of leukemic transformation. Aberrant JAK2 signaling plays an etiological role in MPN formation. Because neoplastic cells in patients are largel...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Mazzacurati, Lucia, Lambert, Que T., Pradhan, Anuradha, Griner, Lori N., Huszar, Dennis, Reuther, Gary W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741885/
https://ncbi.nlm.nih.gov/pubmed/26472029
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