The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

Classical myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders that exhibit excess mature myeloid cells, bone marrow fibrosis, and risk of leukemic transformation. Aberrant JAK2 signaling plays an etiological role in MPN formation. Because neoplastic cells in patients are largel...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mazzacurati, Lucia, Lambert, Que T., Pradhan, Anuradha, Griner, Lori N., Huszar, Dennis, Reuther, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741885/
https://ncbi.nlm.nih.gov/pubmed/26472029
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