Activation of JAK2-V617F by Components of Heterodimeric Cytokine Receptors

The JAK2-V617F mutation is an important etiologic factor for the development of myeloproliferative neoplasms. The mechanism by which this mutated tyrosine kinase initiates deregulated signals in cells is not completely understood. It is believed that JAK2-V617F requires interactions with homodimeric...

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Autors principals: Pradhan, Anuradha, Lambert, Que T., Griner, Lori N., Reuther, Gary W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878064/
https://ncbi.nlm.nih.gov/pubmed/20363735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071191
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