IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

Prior studies implicate type 1 IGF receptor (IGF-1R) in mediating chemo-resistance. Here, we investigated whether IGF-1R influences response to temozolomide (TMZ), which generates DNA adducts that are removed by O(6)-methylguanine-DNA methyltransferase (MGMT), or persist causing replication-associat...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ramcharan, Roger, Aleksic, Tamara, Kamdoum, Wilfride Petnga, Gao, Shan, Pfister, Sophia X., Tanner, Jordan, Bridges, Esther, Asher, Ruth, Watson, Amanda J., Margison, Geoffrey P., Woodcock, Mick, Repapi, Emmanouela, Li, Ji-Liang, Middleton, Mark R., Macaulay, Valentine M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741867/
https://ncbi.nlm.nih.gov/pubmed/26497996
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