Loading...

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chr...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Ambrosini, Grazia, Sawle, Ashley D., Musi, Elgilda, Schwartz, Gary K.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741774/
https://ncbi.nlm.nih.gov/pubmed/26397223
Tags: Add Tag
No Tags, Be the first to tag this record!