BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chr...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Ambrosini, Grazia, Sawle, Ashley D., Musi, Elgilda, Schwartz, Gary K.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741774/
https://ncbi.nlm.nih.gov/pubmed/26397223
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