Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be fully understood. We have recently demonstrated that the G-protein estrogen receptor (GPER) cooperates with hypoxia inducible factor-1α (HIF-1α) toward the regulation of the pro-angiogenic factor VEGF. Here, we sho...

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Publicat a:Oncotarget
Autors principals: Rigiracciolo, Damiano Cosimo, Scarpelli, Andrea, Lappano, Rosamaria, Pisano, Assunta, Santolla, Maria Francesca, De Marco, Paola, Cirillo, Francesca, Cappello, Anna Rita, Dolce, Vincenza, Belfiore, Antonino, Maggiolini, Marcello, De Francesco, Ernestina Marianna
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper: Pathology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741443/
https://ncbi.nlm.nih.gov/pubmed/26415222
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