HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs)

INTRODUCTION: Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess a unique microenvironment characterized by local hypoxia, which induces gene expression changes and biological features leadi...

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Detalhes bibliográficos
Main Authors: De Francesco, Ernestina Marianna, Lappano, Rosamaria, Santolla, Maria Francesca, Marsico, Stefania, Caruso, Arnaldo, Maggiolini, Marcello
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978922/
https://ncbi.nlm.nih.gov/pubmed/23947803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3458
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